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Best of Vietnam and Cambodia River Cruise

This epic cruise showcases Vietnamese and Cambodian history, heritage, and culture with a carefully planned itinerary that adds hotel stays to complement your time on the water.

Signature Experiences and Freedom of Choice days offer guided educational excursions, unique tours, and free time so guests can craft a personal holiday and focus on specific areas of interest.

Whether on board or in a hotel, enjoy five-star luxury, award-winning international and Asian cuisine, and warm, discreet service, the perfect complement to your voyage of exploration and discovery on the Mighty Mekong River.

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from 401 reviews
  • Cruise Line: APT Touring
  • Ship: Mekong Serenity
  • Duration: 21 Nights
  • Departure: December
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Best of Vietnam and Cambodia Cruise Itinerary

This 22-night holiday is an epic voyage of discovery into the history, culture, and heritage of Cambodia and Vietnam. Enjoy hand-picked educational excursions, famous landmarks, and hidden gems. There is plenty of free time to explore and experience the beautiful scenery and cuisines with a mix of hotel stays and luxury accommodation on board a stylish and elegant cruise vessel.

Day 1


Board a flight from London to Vietnam.

Day 2

Arrive in Ho Chi Minh City

AP Touring’s Signature Experience allows fast track service through Ho Chi Minh City airport. An APT representative greets guests to take them to their accommodation. Enjoy a Welcome Dinner.

Day 3

Ho Chi Minh City

Today is all about APT’s legendary Signature Experiences. Visit the Cu Chi Tunnels built by the Viet Cong during the Vietnam War, or meet a Master Gin Distiller and enjoy a private tasting. Dinner is at the internationally renowned Vietnam House.

Day 4

Ho Chi Minh City, Da Nang, Hoi An

Day Four is all about Freedom of Choice options. Take a walking tour of Ho Chi Minh City or see the sights from the back of a motorbike. For inner peace, join a Tai Chi session or improve your Southeast Asian cooking with a culinary class. Later, fly to Da Nang and then transfer to the ancient lantern-lit town of Hoi An.

Day 5

Hoi An

Enjoy a Signature Experience in Hoi An with a visit to the local market to find ingredients for an exclusive cookery class. A guided tour of this ancient and cultural town includes the Japanese Covered Bridge and a visit to a local handicraft workshop. Later on, travel by boat along the Thu Bon River.

Day 6

Hoi An, Hue

Witness authentic Vietnamese rural life on an agricultural eco-tour with APT’s Signature Experience. Observe different farming activities, then explore the coconut palm jungle by basket boat. Guests also visit Hue, the former Imperial Capital, travelling via Da Nang and over the stunningly scenic Hai Van Pass.

Day 7


Enjoy afternoon tea as you sail Hue’s Perfume River. Visit the Imperial Citadel and wander among the monuments built during the Nguyen Dynasty. Guests also visit the Tien Mu Pagoda Buddhist Monastery with its beautiful gardens.

Day 8

Hue, Hanoi

Before flying to Hanoi from Phu Bai International Airport, snatch a little time to wander through the vibrant and colourful Dong Ba market. Dine at the acclaimed Spice Garden Restaurant in Hanoi.

Day 9


You design your day. Choose a tour of the ancient village of Bat Tang, indulge yourself in a body massage at the hotel, or discover Hanoi’s French colonial architecture on a walking excursion. There is also the option of an in-depth guided tour of Hanoi, and guests can choose their dining experience.

Day 10

Hanoi, Tuan Chau, Embark Ship Ha Long Bay

Join a local historian for a private tour of the hotel’s famous bomb shelter before travelling by coach to Ha Long for a three-day cruise amongst the islets. Enjoy gourmet Vietnamese cuisine with the option to swim or kayak in the bay’s green waters.

Day 11

Ha Long Bay

Start the day on board your vessel with a Tai Chi class before disembarking later on to visit Viet Hai Village. Lunch, swim, sunbathe before returning to the ship, and then sightsee around Cua Van Floating Village, one of the world’s most beautiful destinations, by kayak or rowing boat.

Day 12

Ha Long Bay, Tuan Chau, Disembark Ship, Hanoi, Siem Reap

Visit Sung Sot Cave, the largest cave in Ha Long Bay, with thousands of stalagmites and stalactites, before lunching on board ship as you return to port. A flight will take you from Hanoi to Siem Reap in Cambodia, with a choice of restaurants for dinner.

Day 13

Siem Reap

Choose from two Signature Experiences, including a VIP tour at Phare Circus or an exploration of the World Heritage-listed Angkor Archaeological Park, the capital of the 12th century Khmer Empire, and a complex of Hindu and Buddhist monuments.

Day 14

Siem Reap

Experience the beauty of the unique sunrise at Angkor Archaeological Park or enjoy a private visit to Theam’s Gallery, followed by a five-course Khmer dinner with a traditional Apsara dance performance. Free time is allocated for activities, including a quad bike adventure, bike tour, shopping, or spa treatment.

Day 15

Siem Reap, Kampong Cham, Embark Ship, Koh Pen, Angkor Ban

Discover Cambodian riverside life from a tuk tuk tour before travelling to Kampong Cham, where guests board the Mekong Serenity. Cruise to the island of Koh Pen with its iconic stilt houses and enjoy the flavours of local cuisine at your Welcome Dinner.

Day 16

Angkor Ban, Koh Oknha Tey, Phnom Penh

Join a walking tour of Angkor Ban, one of the few surviving villages from the Khmer Rouge regime. Later, sail to Koh Oknha Tey, a renowned centre for silk weaving and famed for its traditional stilt houses.

Day 17

Phnom Penh

See firsthand Cambodia’s savage history with a visit to the Killing Fields and Tuol Sleng Genocide Museum. There is also the option to discover Phnom Penh on a bike tour. Visit the National Museum, the Royal Palace, and the Silver Pagoda.

Day 18

Phnom Penh, Oudong

Discover Oudong, a sacred place of pilgrimage, and receive a Buddhist Blessing at a local monastery. Before returning to the ship, stroll through Koh Chen and visit the copper workshops. There is also free time to explore Phnom Penh.

Day 19

Phnom Penh, Border Crossing, Tan Chau

Your ship cruises towards the Vietnamese border with on board culinary sessions like fruit carving or creating those delicious spring rolls. Guests can relax with a spa treatment whilst your cruiser heads towards the riverside town of Tan Chau.

Day 20

Tan Chau, Evergreen Island, Sa Dec

A small boat tour takes guests along the tiny tributaries around Tan Chau, where there is a floating fish farm. Enjoy a rickshaw tour of Tan Chau and visit a silk and rattan weaving workshop, followed by a visit to Evergreen Island, a chance to see authentic rural life by the Mekong.

Day 21

Sa Dec, Cai Be, My Tho

Take a small tender to Sa Dec and visit the home of best-selling French writer Marguerite Duras and learn the story behind her famous novel. This is followed by a tour of a traditional Cao Dai temple before the ship cruises to Cai Be.

Day 22

My Tho, Disembark Ship, Depart for Ho Chi Minh City

Leave your cruiser at My Tho and travel to Ho Chi Minh City before transferring to Tan Son Nhat International Airport for flights back to the UK.

Best of Vietnam and Cambodia Cruise Ships

Mekong Serenity

Recline aboard APT’s newest and most luxurious ship on the Mekong. Featuring 44 elegant suites, private outdoor balconies, indoor panoramic balconies and much more – this floating hotel is designed to cater to guests’ every whim.

Launched in 2023
44 Crew Members
Six-course Dining Experience

Trustpilot Reviews

Best of Vietnam and Cambodia Deals

Cruise the Mekong and experience culture & history

21 Nights

Best of Vietnam and Cambodia

  • Angkor Ban / Koh Oknha Tey
  • Da Nang
  • Ha Long Bay
  • Hanoi
  • Ho Chi Minh City
  • Hoi An
  • Hue
  • London
  • Phnom Penh
  • Phnom Penh / Oudong
  • Sa Dec / Cai Be / My Tho
  • Siem Reap
  • Tan Chau / Evergreen Island / Sa Dec
£8,395pp Est. Price per person
  • Mekong Serenity  

Best of Vietnam and Cambodia Cruise Review

“As experienced cruisers, this trip was a first for us as we have previously only ever cruised in Europe. Well, what a fascinating place to visit. Because so much of Southeast Asian life is focused on the Mekong, this is such a great way to explore the culture and heritage, plus the scenery is amazing. This vessel was outstanding, with low passenger numbers, a warm, intimate atmosphere, and every facility you could want. I would recommend this cruise to anyone.”

Shuan and Avril,Bicester

Best of Vietnam and Cambodia FAQ

Find answers to some of the most common questions about river cruising here.

What visas do I need for this cruise?

Our expert and friendly booking team will advise you of visa requirements when you make your reservation. Plan ahead, as visa applications can take 3-4 months. Some destinations require an invitation letter as part of the visa application. APT can supply this when you book.

Is tipping included on my APT cruise?

Tipping is included on all APT cruises, but if there are destinations on your cruise where tipping is not included, then your APT sales agent will advise you when you book.

Will I have internet access on board the ship?

Free Wi-Fi is available throughout the Mekong Serenity for the duration of your cruise. There can be some fluctuations in coverage due to remote locations or weather conditions, and the captain and staff will let passengers know. You should easily be able to stay in touch with friends and family.

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